Damage to Chromosomal and Plasmid DNA by Toxic Oxygen Species
نویسندگان
چکیده
منابع مشابه
Lymphocyte dysfunction after DNA damage by toxic oxygen species. A model of immunodeficiency
The metabolic causes for immune impairment in patients with severe chronic inflammatory diseases have not been clearly defined. Recently, the overproduction of poly(ADP-ribose) in resting lymphocytes with unrepaired DNA strand breaks has been suggested to contribute to immune dysfunction in adenosine deaminase-deficient patients. Our experiments have determined to what extent DNA damage and pol...
متن کاملBrief Definitive Report Lymphocyte Dysfunction after Dna Damage by Toxic Oxygen Species a Model of Immunodeficiency
Immune attri t ion may occur in association with severe chronic infections and neoplastic diseases (1). Mechanisms o f immunodeficiency in these disorders have not been elucidated precisely. During inf lammatory states, activated neutrophils release toxic oxygen species into the extracellular envi ronment (2). T h e oxygen products can damage the DNA of adjacent cells (3). T h e accumulation of...
متن کاملReactive oxygen species and oxidative DNA damage.
Reactive oxygen species (ROS) such as the superoxide anion radical (O2.-) hydrogen peroxide (H2O2) and hydroxyl radical (.OH) have been implicated in the pathophysiology of various states, including ischemia reperfusion injury, haemorrhagic shock, atherosclerosis, heart failure, acute hypertension and cancer. The free radicals, nitric oxide (NO) and O2.- react to form peroxynitrite (ONOO-), a p...
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Pharmacoepidemiologic studies provide evidence that use of metformin, a drug commonly prescribed for type II diabetes, is associated with a substantial reduction in cancer risk. Experimental models show that metformin inhibits the growth of certain neoplasms by cell autonomous mechanisms such as activation of AMP kinase with secondary inhibition of protein synthesis or by an indirect mechanism ...
متن کاملReactive oxygen species and death: oxidative DNA damage in atherosclerosis.
Oxidative Modification of LDL Although LDL is essential to deliver cholesterol to tissues, increased LDL cholesterol is associated with increased risk of cardiovascular disease. Oxidative modification of LDL promotes recruitment and retention of monocytes3 with formation of fatty streaks, the earliest lesions in atherosclerosis.4 Both macrophages and vascular smooth muscle cells (VSMCs) bind ox...
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ژورنال
عنوان ژورنال: Microbiology
سال: 1985
ISSN: 1350-0872,1465-2080
DOI: 10.1099/00221287-131-12-3325